Universidade Federal do Rio de Janeiro, Brazil
Metabolite produced by Streptomyces possesses antiviral activity
Published in Law and Health Weekly, July 22nd, 2006
Researchers in Brazil conducted a study "to investigate the antiviral potential of the macrolide FK506, produced by Streptomyces tsukubaensis, against Orthopoxvirus infection in cell culture, and determine the replicative stage of viral cycle affected by the treatment. Cell lines were infected with different Orthopoxviruses and treated with FK506. The macrolide inhibited the replication of the prototypic Orthopoxvirus, vaccinia virus strain WR, with an IC50 of 12.05 micromole/L."
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