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University of Salamanca, Spain

p53 downregulates its activating vaccinia-related kinase 1

Published in Law and Health Weekly, August 26th, 2006

p53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loop

According to a report from Spain, "The stable accumulation of p53 is detrimental to the cell because it blocks cell growth and division. Therefore, increases in p53 levels are tightly regulated, mainly by its transcriptional target, mdm2, that downregulates p53."

"Elucidation of new signaling pathways requires the characterization of the members and the nature of their connection. Vaccinia-related kinase 1 (VRK1) contributes to p53 stabilization by partly interfering with its mdm2-mediated degradation, among other mechanisms; therefore, it is likely that...

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