Aichi Cancer Center, Aichi, Japan
Researchers' work from Japan, the United States and Italy adds to lymphoma body of knowledge
Published in Law and Health Weekly, August 26th, 2006
Study 1: REL might be more involved than BCL11A in the pathogenesis of diffuse large B-cell lymphoma (DLBCL).
"Amplification of 2p has been observed as a recurrent alteration in DLBCL. Whereas two candidate oncogenes, REL and BCL11A, have been investigated as targets for 2p amplification, the question remains as to whether the true target gene in the amplicon is REL, BCL11A or both. We previously identified frequent genomic gains of chromosomal 2p in 25 out of 99 DLBCL cases by means of genome-wide array comparative genomic hybridization (CGH). All of these 25...
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