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University of Michigan, U.S.

Glioma patients' vascular permeability and cerebral blood volume estimated using Gd-DTPA and MRI

Published in Law and Health Weekly, October 14th, 2006

Vascular permeability and cerebral blood volume (CBV) in glioma could be estimated using gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) contrast enhancement and dynamic T2*-weighted MRI.

According to researchers from the United States, "To develop a numerical approach for estimation of vascular permeability from dynamic T2*-weighted imaging, a technique routinely used to measure CBV and flow in gliomas. This study describes a process for estimating both the Gd-DTPA transvascular transfer constant and CBV from dynamic T2*-weighted images. The algorithm was applied to data from the brains of 12 patients with grade IV gliomas."

"The stability...

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