Cardiovascular Research

Two drugs may stabilize plaques in atherosclerosis

Published in Law and Health Weekly, December 9th, 2006

Two drugs that a Wake Forest University School of Medicine research team has been investigating for lupus for several years may stabilize atherosclerotic plaque in the walls of arteries and help avert heart attacks and strokes.

Nilamadhab Mishra, MD, and colleagues reported at the American College of Rheumatology meeting in Washington that the two drugs - TSA (trichostatin A) and SAHA (suberoylanilide hydroxamic acid ) - decreased cholesterol deposits in the walls of arteries.

The two drugs are part of a class of drugs called histone deacetylase inhibitors, or HDIs, which work by multiple mechanisms, one of which is anti-inflammatory: they decreased...

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Source: Law and Health Weekly (2006-12-09)

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