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Breast Cancer

Epigenetics Could Lead to Better Cancer Diagnosis

Published in Law and Health Weekly, March 17th, 2007

DNA methylation is an epigenetic process that occurs when a methyl group binds to one of DNA’s four bases, cytosine. These changes are responsible for controlling the activity of genes by turning them off. DNA methylation patterns differ dramatically between healthy and diseased tissue and thereby can serve as biomarkers, opening a window into earlier detection of disease. In a special issue of the journal Disease Markers published in February 2007, ten articles explore the details and challenges of cancer epigenetics.

Writing in the editorial, Guest Editor Martin Widschwendter (Institute for Women’s Health, University College London) emphasizes that, “The concept of...

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