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Obesity and Diabetes

Neurogen Announces Results of First-in-Human Trial for New Approach to Treating Obesity

Published in Law and Health Weekly, May 19th, 2007

Neurogen Corporation (Nasdaq: NRGN) announced that it has completed a single ascending dose, first-in-human study with NGD-4715, the Company's leading drug candidate for the treatment of obesity. NGD-4715 works as a small molecule antagonist at the melanin concentrating hormone receptor-1 (MCHR1). The compound was safe and well tolerated at all doses studied in this clinical trial.

MCHR1 represents a new biological target for treating obesity and is the subject of research programs at many major pharmaceutical companies. Neurogen believes its MCHR1 program may be the most advanced in the industry. NGD-4715 and other compounds in the Company's MCHR1 obesity program are...

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