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ArQule, Inc.

ArQule Announces Offering of Common Stock

Published in Law and Health Weekly, June 23rd, 2007

ArQule, Inc. ("ArQule" or the "Company") (NASDAQ: ARQL) announced that it has filed a preliminary prospectus supplement to an existing shelf registration statement with the Securities and Exchange Commission relating to a proposed public offering of 7,000,000 shares of its common stock. In connection with the offering, ArQule expects to grant its underwriters a 30-day option to purchase up to 1,050,000 shares at the public offer price to cover over-allotments, if any.

UBS Investment Bank and CIBC World Markets are acting as joint book-running managers for this offering. Leerink Swann & Company and Fortis Securities LLC are co-managers.

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