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DNA Research
Research from City University of New York in DNA research provides new insights
September 6th, 2008
"Mdm2, as the most important negative regulator of p53, plays an important homeostatic role in regulating cell division and the cellular response to DNA damage, oncogenic insult and other forms of cellular stress. We discovered that the DNA damaging agent adriamycin (doxorubicin) induces a novel aberrantly spliced Mdm2 mRNA which incorporates 108 bp of intronic sequence not normally found in the Mdm2 mature mRNA," scientists in the United States report. "Accordingly, we term this Mdm2 splice variant Mdm(2+) (108). Importantly, this insertion introduces in-frame nonsense codons, thus encoding a profoundly truncated mdm2 protein lacking the C-terminal RING finger domain...
Source: Law & Health Weekly (2008-09-06)
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