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Enzyme Research
New enzyme research research from V.I. Ugarov and colleagues discussed
September 13th, 2008
According to recent research from Russia, "Q beta replicase (RNA-directed RNA polymerase of bacteriophage Q beta) exponentially amplifies certain RNAs in vitro. Previous studies have shown that Q beta replicase can initiate and elongate on a variety of RNAs; however, only a minute fraction of them are recognized as 'legitimate' templates." "Guanosine 5'-triphosphate (GTP)-dependent initiation on a legitimate template generates a stable replicative complex capable of elongation in the presence of aurintricarboxylic acid, a powerful inhibitor of RNA-protein interactions. On the contrary, initiation on an illegitimate template is GTP independent and does not result in the...
Source: Law & Health Weekly (2008-09-13)
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