Gilead Sciences, Inc.
Phase III Study of Gilead’s Darusentan for Resistant Hypertension Meets Primary Endpoints
Published in Law and Health Weekly, April 25th, 2009
Gilead Sciences, Inc. (Nasdaq: GILD) announced that DAR-311 (DORADO), a Phase III clinical trial evaluating the company’s endothelin receptor antagonist (ERA) darusentan for the treatment of resistant hypertension, met its co-primary efficacy endpoints of change from baseline to week 14 in trough sitting systolic blood pressure (SBP) and trough sitting diastolic blood pressure (DBP). DORADO is one of two ongoing Phase III clinical trials evaluating the safety, efficacy and tolerability of darusentan as an add-on treatment for resistant hypertension, defined as the failure to achieve goal blood pressure while adhering to full doses of an appropriate three-drug regimen that includes a...
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