University of Pennsylvania

Antidepressants may change personality, leading to reduced depression, says Penn collaboration

Published in Law and Health Weekly, January 16th, 2010

Examining data obtained from a University of Pennsylvania and Vanderbilt University psychology study, researchers at these universities and Northwestern University have reported the first placebo-controlled evidence that antidepressant medications-particularly selective serotonin reuptake inhibitors, or SSRIs-can substantially change patients' personalities. The personality changes also appeared to be linked to long-term improvements in mood.

The findings counter the common assumption that personality changes during SSRI treatment occur only as a byproduct of alleviating depressive symptoms. In this study, the advantage of paroxetine over placebo in changing personality...

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Source: Law and Health Weekly (2010-01-16)

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