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Aging
Activation of AMPK by in vivo hypoxia is slower than in vitro
January 25th, 2005
A recent report on the effects of aging on cardiac and skeletal muscle AMPK activity describes basal activity, allosteric activation, and response to in vivo hypoxemia in mice. According to a study from the Untied States, "Although a diminished ability of tissues and organisms to tolerate stress is a clinically important hallmark of normal aging, little is known regarding its biochemical basis. Our goal was to determine whether age-associated changes in AMP-activated protein kinase (AMPK), a key regulator of cellular metabolism during the stress response, might contribute to the poor stress tolerance of aged cardiac and skeletal muscle." A.A....
Source: Life Science Weekly (2005-01-25)
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