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Aging
Food intake in elderly rats studied, ineffectiveness of orexin-A revealed
January 25th, 2005
According to recently published research from Japan, orexin-A does not stimulate food intake in old rats. "Aging is associated with a progressive decrease in appetite and food intake. Both A and B orexins, expressed in specific neurons of the lateral hypothalamic area, have been implicated in the regulation of sleep and feeding," wrote S. Takano and colleagues. "In this study, the stimulatory effect of intracerebroventricular administration of the orexins on food intake was compared between young (4-mo-old) and old (25- to 27-mo-old) male Wistar rats. "A stainless steel cannula was implanted stereotactically into the left lateral...
Source: Life Science Weekly (2005-01-25)
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