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Alzheimer Disease
Method for screening beta-amyloid secretion inhibitors developed
January 25th, 2005
Researchers have developed a method for the high-throughput screening of beta-amyloid secretion inhibitors using homogenous time-resolved fluorescence. According to a study from Italy, "A cell-based assay using homogeneous time-resolved fluorescence has been developed for high throughput screening of putative beta-amyloid (A-beta) production inhibitors. In this assay, total A-beta is detected by simply adding two commercially available antibody complexes. The first was a biotinylated monoclonal antibody (4G8), specifically recognizing an epitope comprising the residues 17-24 of the A-beta peptide, complexed with europium cryptate-streptavidin conjugate. The second was a...
Source: Life Science Weekly (2005-01-25)
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