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Alzheimer Disease
New research in the area of Alzheimer disease detailed
January 25th, 2005
Investigators in the United States, Japan and Canada have published new Alzheimer disease data. Study 1: Researchers from the United States have documented aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation. "The Arctic mutation within the amyloid-(A) peptide causes Alzheimer disease. In vitro, Arctic-mutant A forms (proto) fibrils more effectively than wild-type A. We generated transgenic mouse lines expressing Arctic-mutant human amyloid precursor proteins (hAPP). "Amyloid plaques formed faster and were more extensive in Arctic mice than in hAPP mice expressing wild-type A, even though...
Source: Life Science Weekly (2005-01-25)
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