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Alzheimer Disease
Phosphorylated eukaryotic translation factor 4E heightened in Alzheimer brain
January 25th, 2005
Levels of phosphorylated eIF4E in the brain are significantly elevated in Alzheimer disease patients. "Eukaryotic translation factor 4E (eIF4E) plays a key role in regulating protein translation," scientists in Sweden explained. "It was thought that in order to maintain neuronal functions, tau protein is continuously generated to compensate those being hyperphosphorylated and compromised in its ability to promote and maintain microtubule assembly in Alzheimer disease." "If eIF4E is involved in tau mRNA translation, level of eIF4E phosphorylation should be changed," noted X. Li and colleagues at the Karolinska Institute. In a recent study, they "found...
Source: Life Science Weekly (2005-01-25)
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