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Alzheimer Disease
Synaptic targeting by AD-related amyloid beta oligomers provide disease clues
January 25th, 2005
Synaptic targeting by Alzheimer-related amyloid beta oligomers may provide a molecular basis for the specific loss of memory function in early Alzheimer disease (AD). According to a study from the United States, "The cognitive hallmark of early Alzheimer's disease (AD) is an extraordinary inability to form new memories. For many years, this dementia was attributed to nerve-cell death induced by deposits of fibrillar amyloid beta(Abeta). A newer hypothesis has emerged, however, in which early memory loss is considered a synapse failure caused by soluble Abeta oligomers." "Such oligomers rapidly block long-term potentiation, a classic experimental...
Source: Life Science Weekly (2005-01-25)
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