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Anesthesia
Propofol not recommended for long-term sedation of critically ill
January 25th, 2005
Propofol infusion syndrome was the focus of a recent report. According to the report from Germany, "Propofol infusion syndrome has not only been observed in patients undergoing long-term sedation with propofol, but also during propofol anesthesia lasting 5 hours. It has been assumed that the pathophysiologic cause is propofol's impairment of oxidation of fatty acid chains and inhibition of oxidative phosphorylation in the mitochondria, leading to lactate acidosis and muscular necrosis. It has been postulated that propofol might act as a trigger substrate in the presence of priming factors." J. Motsch and J. Roggenbach of the University Clinic in...
Source: Life Science Weekly (2005-01-25)
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