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Angiology
Beta arrestin activity studied, need for angiotensin receptor revealed
January 25th, 2005
According to a study from the United States, a stable interaction between beta-arrestin 2 and angiotensin type 1A (AT(1A)) receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2. "Receptors not only leads to receptor desensitization and endocytosis but also elicits additional signaling processes. We recently proposed that stimulation of the AT(1A) receptor results in independent beta-arrestin 2- and G protein-mediated extracellular signal-regulated kinases 1 and 2 (ERK1/2) activation. "Here we utilize two AT(1A) mutant receptors to study these independent pathways, one truncated at residue 324,...
Source: Life Science Weekly (2005-01-25)
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