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Angiology
Structure of angiotensin I-converting enzyme revealed
January 25th, 2005
Recently published research from England elucidated the structure of the angiotensin I-converting enzyme (ACE). "ACE is a zinc- and chloride-dependent metallopeptidase that plays a vital role in the metabolism of biologically active peptides. Until recently, much of the inhibitor design and mechanism of action of this ubiquitous enzyme was based on the structures of carboxypeptidase A and thermolysin. "When compared to the recently solved structures of the testis isoform of ACE (tACE) and its Drosophila homologue (AnCE), carboxypeptidase A showed little structural homology outside of the active site, while thermolysin revealed significant but less...
Source: Life Science Weekly (2005-01-25)
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