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Angiology
Thrombosis and infarction associated with collagen receptor polymorphism
January 25th, 2005
Researchers from Finland have reported that platelet membrane collagen receptor glycoprotein VI polymorphism is associated with coronary thrombosis and fatal myocardial infarction in middle-aged men. "Glycoprotein VI is a platelet collagen receptor binding to subendothelial collagen after a rupture of an atherosclerotic plaque. The GPVI gene is polymorphic with several SNPs and the T13254C polymorphism predicting amino acid substitution (serine to proline) has been associated with the risk of MI in a preliminary study. "We studied the association of the GPVI T13254C with fatal myocardial infarction (MI) and coronary artery disease among the 300 men...
Source: Life Science Weekly (2005-01-25)
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