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Angiology

VEGF isoforms reveal a time-related response to hypoxia in the knee joint

According to recent research from the United States, "vascular endothelial growth factor (VEGF) gene gives rise to several distinct isoforms of VEGF, which differ in their expression patterns as well as their biochemical and biological properties."

"We examined the expression levels of VEGF isoforms and their receptors in the medial and lateral meniscus of rabbits under normal physiologic conditions as well their expression levels after 8 and 24 hours (h) of systemic normobaric hypoxia (13%). VEGF₁₂₁ is the most abundant VEGF isoform in the medial and lateral...

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