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Angiology
Vascular smooth muscle viability is pertinent to tumor biology
January 25th, 2005
Vascular smooth muscle viability is pertinent to tumor biology. "Little is known about the interaction of tumor cells with host vascular smooth muscle cells. In reconstitution experiments, tumorigenic cell lines (including the rat hepatocarcinoma Morris 7777 and human melanoma M-21) were cultured for 17 hours in the presence of rat aortic rings, subsequently evaluated in contractility assays (response to phenylephrine and potassium chloride). An agonist-independent loss of contractility was observed in rings pre-incubated with either tumorigenic cell lines or their conditioned medium (CM)," scientists in Canada report. "The depressing effect of...
Source: Life Science Weekly (2005-01-25)
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