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Glomerulosclerosis
Studies from L.H. Bao and co-researchers update current data on glomerulosclerosis
July 14th, 2009
"Heritable and acquired diseases of podocytes can result in focal and segmental glomerulosclerosis (FSGS). We modeled FSGS by passively transferring mouse podocyte-specific sheep Abs into BALB/c mice," investigators in the United States report. "BALB/c mice deficient in the key complement regulator, decay-accelerating factor (DAF), but not WT or CD59-deficient BALB/c mice developed histological and ultrastructural features of FSGS, marked albuminuria, periglomerular monocytic and T cell inflammation, and enhanced T cell reactivity to sheep IgG. All of these findings, which are characteristic of FSGS, were substantially reduced by depleting CD4(+) T cells from Daf(-/-)...
Source: Life Science Weekly (2009-07-14)
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