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Lymphedema
Reports outline lymphedema study results from University of Queensland, Institute for Molecular Bioscience
July 21st, 2009
Investigators publish new data in the report 'Vascular defects in a mouse model of hypotrichosis-lymphedema-telangiectasia syndrome indicate a role for SOX18 in blood vessel maturation.' "Mutations in the transcription factor gene SOX18 cause vascular, lymphatic and hair follicle defects in humans with dominant and recessive forms of hypotrichosis-lymphedema-telangiectasia (HLT) syndrome. Here, we clarify the role of SOX18 in the vascular dysfunction in HLT by ultrastructural, immunofluorescence, molecular and functional analysis of vascular anomalies in embryos of the naturally occurring Sox18-mutant mouse strain ragged-opossum (Ra(Op))," scientists writing in the journal Human...
Source: Life Science Weekly (2009-07-21)
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