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Karolinska University Hospital

Neonatal eosinophils analyzed, nature of transmigration established

Published in MD Week, September 2nd, 2005

According to a study from Sweden, neonatal eosinophils possess efficient eotaxin/IL-5- and N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced transmigration in vitro.

"The majority of premature infants develop eosinophilia and abnormalities in eosinophil trafficking during the first period of postnatal life. We therefore thought to assess the ability of neonatal eosinophils to transmigrate in vitro toward chemotactic stimuli mimic either bacterial infections, or to allergic inflammation in vivo, and to compare the results with eosinophils in adults," wrote A. Moshfegh and colleagues, Karolinska University Hospital.

"We used an in vitro...

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