Trichomoniasis

Heme-iron increases levels of parasite adherence to vaginal epithelial cells

Published in Malaria Weekly, June 21st, 2004

Continuing their work on sources of iron that regulate Trichomonas vaginalis virulence genes, University of Texas microbiologists report that heme-bound iron increases levels of the parasite's adherence to vaginal epithelial cells.

"Trichomonas vaginalis is a protozoan responsible for the number one, non-viral sexually transmitted disease," said J.F. Alderete and colleagues.

In the course of infection, "[s]urface proteins (AP65, AP51, AP33, and AP23) mediate adherence to vaginal epithelial cells (VECs). Iron increases growth of trichomonads and synthesis and surface placement of adhesins," they explained.

In their...

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Source: Malaria Weekly (2004-06-21)

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