Malaria Vaccine

Merozoite surface protein antibodies inhibit malaria antibody responses

Published in Malaria Weekly, June 21st, 2004

The maternally derived 19-kDa C-terminal region of merozoite surface protein-1-specific antibodies inhibits the 19-kDa C-terminal region of merozoite surface protein-1-specific antibody responses in neonatal pups.

According to recent research published in the Journal of Immunology, "Immunizing pregnant women with a malaria vaccine is one approach to protecting the mother and her offspring from malaria infection. However, specific maternal antibodies generated in response to vaccination and transferred to the fetus may interfere with the infant's ability to respond to the same vaccine. Using a murine model of malaria, we examined the effect of maternal 19-kDa...

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Source: Malaria Weekly (2004-06-21)

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