Drug Resistance

New findings in the area of drug resistance detailed

Published in Malaria Weekly, November 28th, 2005

Data on drug resistance are outlined in reports from the United Kingdom, Netherlands and Brazil.

Study 1: A study from England has reported on interactions of mefloquine with multidrug resistance proteins (MRPs) present in human red cell membranes.

"Human erythrocyte membranes express the multidrug resistance-associated proteins, MRPI, MRP4 and 5, that collectively can efflux oxidized glutathione, glutathione conjugates and cyclic nucleotides. It is already known that the quinoline derivative, MK-571, is a potent inhibitor of MRP-mediated transport.

"We here examine whether the quinoline-based antimalarial drugs, amodiaquine,...

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Source: Malaria Weekly (2005-11-28)

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