Cholera

Research on cholera published by scientists at University of California

Published in Malaria Weekly, September 22nd, 2008

According to recent research from the United States, "Cholera toxin is a highly efficient biotoxin, which is frequently used as a tool to investigate protein-membrane interactions and as a reporter for membrane rafts. Cholera toxin binds selectively to gangliosides with highest affinity to GM(1)."

"However, the mechanism by which cholera toxin crosses the membrane remains unresolved. Using x-ray reflectivity and grazing incidence diffraction, we have been able to monitor the binding and penetration of cholera toxin into a model lipid monolayer containing the receptor GM1 at the air-water interface. Very high toxin coverage was obtained allowing precise measurements of...

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Source: Malaria Weekly (2008-09-22)

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