Life Sciences

New findings from Vanderbilt University describe advances in life sciences

Published in Malaria Weekly, May 18th, 2009

"Plasmodium protozoa, the source of malarial infections, catabolize large quantities of hemoglobin during an intraerythrocytic phase. During this process, free heme is detoxified through biomineralization into an insoluble heme aggregate, hemozoin (Hz)," scientists writing in the journal Chemical Research in Toxicology report.

"In its native state, Hz is associated with a variety of lipid peroxidation products including 4-hydroxy-2-nonenal (HNE). In the present study, gene expression profiles were used to compare responses to two of the individual components of Hz in a model macrophage cell line. LPS-stimulated RAW 264.7 cells were exposed to HNE and the...

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Source: Malaria Weekly (2009-05-18)

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