Life Sciences
Researchers from University of Liverpool discuss findings in life sciences
Published in Malaria Weekly, May 18th, 2009
"Using a range of laboratory-adapted and genetically modified Plasmodium falciparum parasite isolates, we investigated the interaction between dihydroartemisinin and piperaquine (PIP), the individual components of an artemisinin combination therapy currently under development, in addition to the role of known drug resistance genes in parasite susceptibility in vitro. All but one parasite line investigated displayed an interaction of dihydroartemisinin and PIP that was antagonistic, although the degree of antagonism was isolate dependent," scientists in Liverpool, the United Kingdom report.
"In terms of resistance markers, the pfcrt haplotypes CVIET and SVMNT were...
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Source: Malaria Weekly (2009-05-18)
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