Falciparum Malaria

Study data from National Institutes of Health provide new insights into falciparum malaria

Published in Malaria Weekly, May 18th, 2009

"ATP-binding cassette transporters play an important role in drug resistance and nutrient transport. In the human malaria parasite Plasmodium falciparum, a homolog of the human p-glycoprotein (PfPgh-1) was shown to be involved in resistance to several drugs," scientists in the United States report.

"More recently, many transporters were associated with higher IC50 levels in responses to chloroquine (CQ) and quinine (QN) in field isolates. Subsequent studies, however, could not confirm the associations, although inaccuracy in drug tests in the later studies could contribute to the lack of associations. Here we disrupted a gene encoding a putative multidrug...

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Source: Malaria Weekly (2009-05-18)

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