Life Sciences
Scientists at University of Texas, Center for Emerging Infectious Diseases target life sciences
Published in Malaria Weekly, January 18th, 2010
Investigators publish new data in the report 'The Francisella tularensis pathogenicity island encodes a secretion system that is required for phagosome escape and virulence.' "Francisella tularensis causes the human disease tularemia. F. tularensis is able to survive and replicate within macrophages, a trait that has been correlated with its high virulence, but it is unclear the exact mechanism(s) this organism uses to escape killing within this hostile environment. F. tularensis virulence is dependent upon the Francisella pathogenicity island (FPI), a cluster of genes that we show here shares homology with type VI secretion gene clusters in Vibrio cholerae and Pseudomonas...
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Source: Malaria Weekly (2010-01-18)
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