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Immunoglobulins

Investigators at London School of Hygiene and Tropical Medicine Zero in on Immunoglobulins

Published in Malaria Weekly, August 22nd, 2011

2011 AUG 22 -- New investigation results, "Neutralization of malaria glycosylphosphatidylinositol in vitro by serum IgG from malaria-exposed individuals," are detailed in a study published in Infection and Immunity. "Parasite-derived glycosylphosphatidylinositol (GPI) is believed to be a major inducer of the pathways leading to pathology and morbidity during Plasmodium falciparum infection and has been termed a malaria 'toxin.' The generation of neutralizing anti-GPI ('antitoxic') antibodies has therefore been hypothesized to be an important step in the acquisition of antidisease immunity to malaria; however, to date the GPI-neutralizing capacity of antibodies...

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