Brookhaven National Laboratory

HIV dementia mechanism discovered

Published in Managed Care Business Week, October 12th, 2004

Scientists at the U.S. Department of Energy's Brookhaven National Laboratory have discovered a key mechanism in the brains of people with human immunodeficiency virus (HIV) dementia.

The study is the first to document decreases in the neurotransmitter dopamine in those with the condition, and may lead to new, more effective therapies. HIV dementia is a type of cognitive decline that is more common in the later stages of HIV infection.

"Our results offer the first evidence of dopamine terminal injury - specifically injury to dopamine transporters - in HIV dementia patients," said Brookhaven physician Gene-Jack Wang, the study's lead author. "This...

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Source: Managed Care Business Week (2004-10-12)

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