University of Munich

Gamma-secretase complex assembly within the early secretory pathway revealed

Published in Managed Care Business Week, May 10th, 2005

A study from Germany has clarified gamma-secretase complex assembly within the early secretory pathway.

"Gamma-secretase is an aspartyl protease complex composed of the four core components APH-1, nicastrin (NCT), presenilin (PS), and PEN-2. It catalyzes the final intramembranous cleavage of the beta-secretase-processed beta-amyloid precursor protein to liberate the neurotoxic amyloid A-peptide.

"Whereas unassembled complex components appear to be unstable and/or to be retained within the endoplasmic reticulum (ER), the fully assembled complex is known to exert its biological function in late secretory compartments, including the plasma membrane,"...

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Source: Managed Care Business Week (2005-05-10)

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