Max Planck Institute, Berlin
Alpha-defensins neutralize anthrax toxin & protect against fatal consequences
Published in Managed Care Business Week, July 12th, 2005
According to recent research from Germany, "Anthrax caused by Bacillus anthracis represents a major bioterroristic threat. B. anthracis produces lethal toxin (LeTx), a combination of lethal factor (LF) and protective antigen that plays a major role in anthrax pathogenesis."
"We demonstrate that human neutrophil alpha-defensins are potent inhibitors of LF. The inhibition of LF by human neutrophil protein (HNP-1) was noncompetitive," wrote C. Kim and colleagues at the Max Planck Institute in Berlin.
"HNP-1 inhibited cleavage of...
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