University of Delhi
M. tuberculosis 19-kDa lipoprotein eliminates BCG protection
Published in Managed Care Business Week, July 19th, 2005
"Mycobacterium tuberculosis can not only neutralize immune effector functions, but also has the ability to modulate host-signaling cascades involved in the development of these responses. The 19-kDa antigen (Rv3763), a lipoprotein of M. tuberculosis, elicits high levels of interleukin (IL)-12 from macrophages in addition to its powerful immunomodulatory properties, leading to suppression of antigen-presentation signaling cascades.
"The present study was aimed at...
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