Published in Managed Care Business Week, August 16th, 2005
"Abnormal folding of alpha-synucleln (alpha-syn) is thought to lead to neurodegeneration and the characteristic symptoms of Lewy body disease (LBD). Since previous studies suggest that immunization might be a potential therapy for Alzheimer disease, we hypothesized that immunization with human (h)alpha-syn might have therapeutic effects in LBD. For this purpose, halpha-syn transgenic (tg) mice were vaccinated with halpha-syn," scientists writing in the journal Neuron report.
"In mice that produced high relative affinity antibodies, there was decreased accumulation of...
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