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Catholic University Leuven, Belgium
Insulin spares intensive care patients from organ failure and death
August 16th, 2005
It was previously shown in a large, randomized, controlled trial that controlling blood glucose with insulin reduces the risk of organ failure and death of patients in intensive care. But the underlying mechanisms explaining these clinical benefits remained incompletely understood. In a new study appearing on August 1, 2005, in the Journal of Clinical Investigation, the same group, Greet Van den Berghe and colleagues from Katholieke Universitiet Leuven, showed that there is disturbed microcirculation in these patients that is due to endothelial dysfunction which causes inadequate oxygen supply to the cellular systems. The endothelium controls vascular flow and...
Source: Managed Care Business Week (2005-08-16)
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