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Johns Hopkins University
B lymphocyte activation by HPV-like particles induces Ig class switch
August 16th, 2005
B lymphocyte activation by human papillomavirus-like particles directly induces Ig class switch recombination via TLR4-MyD88. "Vaccination with human papillomavirus type 16 (HPV16) L1 virus-like particles (VLP) induces both high-titer neutralizing IgG and protective immunity. Because protection from experimental infection by papillomavirus is mediated by neutralizing IgG, we sought the mechanisms that trigger humoral immunity to HPV16 L1 VLP," scientists in the United States report. "We find that HPV16 L1 VLP bind to murine B lymphocytes thereby inducing activation-induced cytidine deaminase expression and Ig class switch recombination to cause the...
Source: Managed Care Business Week (2005-08-16)
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