Managed Care Business Week
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Kurashiki Medical Center, Okayama
Induced apoptosis studied, kinase involvement and suppression defined
August 16th, 2005
A recently published study from Japan has documented the involvement of Ras/extracellular signal-regulated kinase, but not protein kinase B (Akt) pathway in risedronate-induced apoptosis of U937 cells and its suppression by cytochalasin B. "Although risedronate, a nitrogen containing bisphosphonate (BPs), strongly inhibits bone resorption by enhanced apoptosis of osteoclasts, its mechanism remained unclear," wrote H. Fujita and colleagues, Kurashiki Medical Center. "In this study, we investigated the molecular mechanism of risedronate-induced apoptosis of U937 cells, with a focus on extracellular signal-regulated kinase 1/2 (ERK 1/2) and Akt...
Source: Managed Care Business Week (2005-08-16)
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