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Korea University, Gyeonggi
Hepatitis B virus-associated liver cancer harbors c-kit-positive tumor cells
August 16th, 2005
Hepatitis B virus-associated liver cancer harbors c-kit-positive tumor cells. According to a study from South Korea, "progenitor cells, termed oval cells, are involved in the pathogenesis of hepatocellular carcinoma (HCC) in animal models. By immunolabeling for c-kit and CD34 in human hepatitis B virus-associated cirrhosis with HCC (50 cases) and those with cirrhosis alone (10 cases), we found c-kit+ tumor cells in tumor tissue in 40 of 50 HCCs." "The proportion was less than 0.1% of total tumor cell volume in most HCCs. Immunostaining for c-kit also was detected in sinusoidal endothelial cells in 43 of 50 HCCs. The incidence of oval cell occurrence...
Source: Managed Care Business Week (2005-08-16)
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