U.S. National Cancer Institute
CypA effects HIV-1 replicative ability such that both high and low CypA limits replication
Published in Managed Care Business Week, March 7th, 2006
"HIV-1 Gag protein interaction with cyclophilin A (CypA) is critical for viral fitness. Among the amino acid substitutions identified in Gag noncleavage sites in HIV-1 variants resistant to protease inhibitors, H219Q (Gatanaga, H. et al., (2002) J. Biol. Chem. 277, 5952-5961) and H219P substitutions in the viral CypA binding loop confer the greatest replication advantage to HIV-1. These substitutions represent polymorphic amino acid residues," scientists writing in the Journal of Biological Chemistry report.
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