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University of Cambridge

Large HIV-specific CD8+ CTL clones maintain high frequencies of memory CTL after HAART

Published in Managed Care Business Week, June 20th, 2006

Large HIV-specific CD8+ cytotoxic T-lymphocyte clones maintain high frequencies of memory CTL following HAART.

According to recent research from England, "Cytotoxic T-lymphocytes (CTL) play an important role in the control of human immunodeficiency virus (HIV) and of human cytomegalovirus (HCMV) infection. Following highly active antiretroviral therapy (HAART), most studies have demonstrated a decline in the frequency of HIV-specific CTL."

"We analyzed the effect of HAART on the size, phenotype and function of individual HIV- and HCMV-specific CTL clones, using clonotypic oligonucleotide probing specific for the T-cell receptor (TCR) beta-chain...

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