Published in Managed Care Law Weekly, June 12th, 2005
Study 1: A recent report describes the interaction of FKBP12.6 with the cardiac ryanodine receptor C-terminal domain.
According to researchers in Wales, "The ryanodine receptor-calcium release channel complex (RyR) plays a pivotal role in excitation-contraction coupling in skeletal and cardiac muscle. RyR channel activity is modulated by interaction with FK506-binding protein (FKBP), and disruption of the RyR-FKBP association has been implicated in cardiomyopathy, cardiac hypertrophy, and heart failure. Evidence for an interaction between RyR and FKBP is well documented, both in...
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