University of Cagliari

Candida albicans examined, histatin-induced effects described

Published in Managed Care Law Weekly, August 28th, 2005

A study from Italy has chronicled mitochondrial alterations and autofluorescent conversion of Candida albicans induced by histatins (Hst).

"The mechanism of the candidacidal activity of Hsts 3 and 5 is still a matter of debate. Previous studies have indicated that Hst induce cell permeabilization, generation of reactive oxygen species (ROS) by mitochondria, inhibition of the respiratory chain, and energy-dependent cytotoxic release of ATP.

"On the other hand, the multiplicity of effects and the apparent contrast between experimental data continue to render the mechanism of Hst-induced killing of C. albicans unclear," wrote G. Diaz and...

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Source: Managed Care Law Weekly (2005-08-28)

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