Managed Care Law Weekly
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Institute Pasteur, Paris
Isomerase activity analyzed, nature of Tau-mediated regulation defined
October 9th, 2005
A recent study from France has reported on the regulation of Pin1 peptidyl-prolyl cis/trans isomerase activity by its WW binding module on a multi-phosphorylated peptide of Tau protein. "The WW module of the peptidyl-prolyl cis/trans isomerase Pin1 targets specifically phosphorylated proteins involved in the cell cycle through the recognition of phospho-Thr(Ser)-Pro motifs. "When the microtubulle-associated Tau protein becomes hyperphosphorylated, it equally becomes a substrate for Pint, with two recognition sites described around the phosphorylated Thr212 and Thr231," wrote C. Smet and colleagues, Institute Pasteur. "The Pin1 WW...
Source: Managed Care Law Weekly (2005-10-09)
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